منابع مشابه
Computational Neurogenetics
Neuroscience, along with information and mathematical sciences, has developed a variety of theoretical and computational models to model complex brain functions. Along with this development, artificial neural networks – computational models that adopt principles from the nervous system, have been developed to become powerful tools for learning from data and generalisation. Artificial neural net...
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The importance for research and clinical utility of mutation databases, as well as the issues and difficulties entailed in their construction, is discussed within the Human Variome Project. While general principles and standards can apply to most human diseases, some specific questions arise when dealing with the nature of genetic neurological disorders. So far, publically accessible mutation d...
متن کاملNeurogenetics, in Caenorhabditis elegans
The human brain is an extraordinarily complex and beautiful organ. It has one hundred billion neurons and an inestimable number of synaptic connections. Since there are very few opportunities to ethically test experimental hypotheses on the human brain, we rely on model organisms to understand how neurons work in humans. Such an organism, the nematode Caenorhabditis elegans, with a total of onl...
متن کاملNeurogenetics II: complex disorders.
The genetic analysis of common neurological disorders will be a difficult and protracted endeavour. Genetics is only one of many disciplines that will be required but it has already thrown considerable light on the aetiology of several major neurological disorders through the analysis of rare inherited subgroups. The identification of individual susceptibility genes with variants of smaller eff...
متن کاملTools for neuroanatomy and neurogenetics in Drosophila.
We demonstrate the feasibility of generating thousands of transgenic Drosophila melanogaster lines in which the expression of an exogenous gene is reproducibly directed to distinct small subsets of cells in the adult brain. We expect the expression patterns produced by the collection of 5,000 lines that we are currently generating to encompass all neurons in the brain in a variety of intersecti...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2002
ISSN: 0022-3050
DOI: 10.1136/jnnp.73.suppl_2.ii26